Amino acids connected to obesity and gut microbiome

Researchers at Lund University in Sweden have discovered a new link between gut bacteria and obesity that certain amino acids in the blood are connected to obesity and the composition of the gut microbiome. The researcher adds to an increasing number of studies, which indicate that the gut microbiota does play an important role in health, affects metabolism and can be linked to obesity, cardiovascular disease and type 2 diabetes. The study, ‘Connection between BMI related plasma metabolite profile and gut microbiota,’ published in The Journal of Clinical Endocrinology & Metabolism.

Previous studies have shown that people with these diseases have varying occurrences of metabolites in the bloodstream. The aim of this study was therefore to identify metabolites in the blood that can be linked to obesity and to investigate whether these obesity-related metabolites affect the composition of the bacterial flora in stool samples.

The researchers analysed blood plasma and stool samples from 674 participants in the Malmö Offspring Study (MOS). They found 19 metabolites that could be linked to the person's BMI; glutamate and so-called BCAA (branched-chain and aromatic amino acids) had the strongest connection to obesity. They also found that the obesity-related metabolites were linked to four intestinal bacteria (Blautia, Dorea and Ruminococcus in the Lachnospiraceae family, and SHA98).

"The differences in BMI were largely explained by the differences in the levels of glutamate and BCAA. This indicates that the metabolites and gut bacteria interact, rather than being independent of each other," said Professor Marju Orho-Melander, professor of genetic epidemiology at Lund University.

By far the strongest risk factor for obesity in the study, glutamate, has been associated with obesity in previous studies, and BCAA has been used to predict the future onset of type 2 diabetes and cardiovascular disease.

"This means that future studies should focus more on how the composition of gut bacteria can be modified to reduce the risk of obesity and associated metabolic diseases and cardiovascular disease," she added. "To get there, we first need to understand what a healthy normal gut flora looks like, and what factors impact the bacterial composition. This requires large population studies, like the Malmö Offspring Study, as well as intervention studies.”